Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases: 2-Volume Set 9th Edition pdf

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For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders.

The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips.

key features of Mandell Douglas and Bennett’s Principles and Practice of Infectious Diseases: 2-Volume Set 9th Edition:

following are the key features of this book given below;

• Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource.
• Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis.
• Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases.
• Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases.
• Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci.
• PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America.

Table of Contents:

• I Basic Principles in the Diagnosis and Management of Infectious Diseases
  A MICROBIAL PATHOGENESIS
  1 A Molecular Perspective of Microbial Pathogenicity
  2 The Human Microbiome of Local Body Sites and Their Unique Biology
  3 Prebiotics, Probiotics, and Synbiotics
  B HOST DEFENSE MECHANISMS
  4 Innate (General or Nonspecific) Host Defense Mechanisms
  5 Adaptive Immunity: Antibodies and Immunodeficiencies
  6 Cell-Mediated Defense Against Infection
  7 Mucosal Immunity
  8 Granulocytic Phagocytes
  9 Complement and Deficiencies
  10 Human Genetics and Infection
  11 Nutrition, Immunity, and Infection
  12 Evaluation of the Patient With Suspected Immunodeficiency
  C EPIDEMIOLOGY OF INFECTIOUS DISEASE
  13 Applied Epidemiology for the Infectious Diseases Physician
  14 Emerging and Reemerging Infectious Disease Threats
  15 Bioterrorism: An Overview
  D CLINICAL MICROBIOLOGY
  16 The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result Interpretation
  E ANTIINFECTIVE THERAPY
  17 Principles of Antiinfective Therapy
  18 Molecular Mechanisms of Antibiotic Resistance in Bacteria
  19 Pharmacokinetics and Pharmacodynamics of Antiinfective Agents
  20 Penicillins and ß-Lactamase Inhibitors
  21 Cephalosporins
  22 Ertapenem, Imipenem, Meropenem, Doripenem, and Aztreonam
  23 Antibiotic Allergy
  24 Fusidic Acid
  25 Aminoglycosides
  26 Tetracyclines, Glycylcyclines, and Chloramphenicol
  27 Rifamycins
  28 Metronidazole
  29 Macrolides and Clindamycin
  30 Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)
  31 Daptomycin and Quinupristin-Dalfopristin
  32 Polymyxins (Polymyxin B and Colistin)
  33 Linezolid, Tedizolid, and Other Oxazolidinones
  34 Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole
  35 Quinolones
  36 Unique Antibacterial Agents
  37 Urinary Tract Agents: Nitrofurantoin, Fosfomycin, and Methenamine
  38 Topical Antibacterials
  39 Antimycobacterial Agents
  40A Antifungal Agents: Amphotericin B
  40B Antifungal Drugs: Azoles
  40C Antifungal Drugs: Echinocandins
  40D Antifungal Drugs: Flucytosine
  41 Antimalarial Drugs
  42 Drugs for Protozoal Infections Other Than Malaria
  43 Drugs for Helminths
  44 Antiviral Agents: General Principles
  45 Antiviral Drugs for Influenza and Other Respiratory Virus Infections
  46 Antivirals Against Herpesviruses
  47 Antiviral Drugs Against Hepatitis Viruses
  48 Miscellaneous Antiviral Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir, Pleconaril)
  49 Immunomodulators
  50 Hyperbaric Oxygen
  51 Antimicrobial Stewardship
  52 Designing and Interpreting Clinical Studies in Infectious Diseases
  53 Outpatient Parenteral Antimicrobial Therapy
  54 Tables of Antiinfective Agent Pharmacology
  
• II Major Clinical Syndromes
  A FEVER
  55 Temperature Regulation and the Pathogenesis of Fever
  56 Fever of Unknown Origin
  57 The Acutely Ill Patient With Fever and Rash
  B UPPER RESPIRATORY TRACT INFECTIONS
  58 The Common Cold
  59 Pharyngitis
  60 Acute Laryngitis
  61 Otitis Externa, Otitis Media, and Mastoiditis
  62 Sinusitis
  63 Epiglottitis
  64 Infections of the Oral Cavity, Neck, and Head
  C PLEUROPULMONARY AND BRONCHIAL INFECTIONS
  65 Acute Bronchitis
  66 Acute Exacerbations of Chronic Obstructive Pulmonary Disease
  67 Acute Pneumonia
  68 Pleural Effusion and Empyema
  69 Bacterial Lung Abscess
  70 Chronic Pneumonia
  71 Cystic Fibrosis
  D URINARY TRACT INFECTIONS
  72 Urinary Tract Infections
  E SEPSIS
  73 Sepsis and Septic Shock
  F INTRAABDOMINAL INFECTIONS
  74 Peritonitis and Intraperitoneal Abscesses
  75 Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis)
  76 Pancreatic Infection
  77 Splenic Abscess
  78 Appendicitis
  79 Diverticulitis and Neutropenic Enterocolitis
  G CARDIOVASCULAR INFECTIONS
  80 Endocarditis and Intravascular Infections
  81 Prosthetic Valve Endocarditis
  82 Infections of Nonvalvular Cardiovascular Devices
  83 Prevention of Infective Endocarditis
  84 Myocarditis and Pericarditis
  85 Mediastinitis
  H CENTRAL NERVOUS SYSTEM INFECTIONS
  86 Approach to the Patient With Central Nervous System Infection
  87 Acute Meningitis
  88 Chronic Meningitis
  89 Encephalitis
  90 Brain Abscess
  91 Subdural Empyema, Epidural Abscess, and Suppurative Intracranial Thrombophlebitis
  92 Cerebrospinal Fluid Shunt and Drain Infections
  I SKIN AND SOFT TISSUE INFECTIONS
  93 Cellulitis, Necrotizing Fasciitis, and Subcutaneous Tissue Infections
  94 Myositis and Myonecrosis
  95 Lymphadenitis and Lymphangitis
  J GASTROINTESTINAL INFECTIONS AND FOOD POISONING
  96 Syndromes of Enteric Infection
  97 Esophagitis
  98 Diarrhea With Little or No Fever
  99 Acute Dysentery Syndromes (Diarrhea With Fever)
  100 Typhoid Fever, Paratyphoid Fever, and Typhoidal Fevers
  101 Foodborne Disease
  102 Tropical Sprue and Environmental Enteric Dysfunction
  K BONE AND JOINT INFECTIONS
  103 Infectious Arthritis of Native Joints
  104 Osteomyelitis
  105 Orthopedic Implant–Associated Infections
  L DISEASES OF THE REPRODUCTIVE ORGANS AND SEXUALLY TRANSMITTED DISEASES
  106 Genital Skin and Mucous Membrane Lesions
  107 Urethritis
  108 Vulvovaginitis and Cervicitis
  109 Infections of the Female Pelvis
  110 Prostatitis, Epididymitis, and Orchitis
  M EYE INFECTIONS
  111 Introduction to Eye Infections
  112 Microbial Conjunctivitis
  113 Microbial Keratitis
  114 Endophthalmitis
  115 Infectious Causes of Uveitis
  116 Periocular Infections
  N HEPATITIS
  117 Viral Hepatitis
  O ACQUIRED IMMUNODEFICIENCY SYNDROME
  118 Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
  119 Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development
  120 Diagnosis of Human Immunodeficiency Virus Infection
  121 The Immunology of Human Immunodeficiency Virus Infection
  122 General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases)
  123 Pulmonary Manifestations of Human Immunodeficiency Virus Infection
  124 Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of Human Immunodeficiency Virus Infection
  125 Neurologic Diseases Caused by Human Immunodeficiency Virus Type 1 and Opportunistic Infections
  126 Human Immunodeficiency Virus Infection in Women
  127 Pediatric Human Immunodeficiency Virus Infection
  128 Antiretroviral Therapy for Human Immunodeficiency Virus Infection
  129 Management of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection
  P MISCELLANEOUS SYNDROMES
  130 Chronic Fatigue Syndrome (Systemic Exertion Intolerance Disease)
  
• III Infectious Diseases and Their Etiologic Agents
  A VIRAL DISEASES
  131 Biology of Viruses and Viral Diseases
  132 Orthopoxviruses Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox
  133 Other Poxviruses That Infect Humans: Parapoxviruses (Including Orf Virus), Molluscum Contagiosum, and Yatapoxviruses
  134 Introduction to Herpesviridae
  135 Herpes Simplex Virus
  136 Chickenpox and Herpes Zoster (Varicella-Zoster Virus)
  137 Cytomegalovirus
  138 Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases)
  139 Human Herpesvirus Types 6 and 7 (Exanthem Subitum)
  140 Kaposi Sarcoma–Associated Herpesvirus (Human Herpesvirus 8)
  141 Herpes B Virus
  142 Adenoviruses
  143 Papillomaviruses
  144 JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy (PML)
  145 Hepatitis B Virus
  146 Hepatitis Delta Virus
  147 Human Parvoviruses, Including Parvovirus B19V and Human Bocaparvoviruses
  148 Orthoreoviruses and Orbiviruses
  149 Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses
  150 Rotaviruses
  151 Alphaviruses (Chikungunya, Eastern Equine Encephalitis)
  152 Rubella Virus (German Measles)
  153 Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika)
  154 Hepatitis C
  155 Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS)
  156 Parainfluenza Viruses
  157 Mumps Virus
  158 Respiratory Syncytial Virus
  159 Human Metapneumovirus
  160 Measles Virus (Rubeola)
  161 Zoonotic Paramyxoviruses: Nipah, Hendra, and Menangle Viruses
  162 Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus)
  163 Rabies (Rhabdoviruses)
  164 Marburg and Ebola Virus Hemorrhagic Fevers
  165 Influenza Viruses, Including Avian Influenza and Swine Influenza
  166 California Encephalitis, Hantavirus Pulmonary Syndrome, Hantavirus Hemorrhagic Fever With Renal Syndrome, and Bunyavirus Hemorrhagic Fevers
  167 Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers (Arenaviruses)
  168 Human T-Cell Leukemia Viruses (HTLV-1, HTLV-2)
  169 Human Immunodeficiency Viruses
  170 Introduction to the Human Enteroviruses and Parechoviruses
  171 Poliovirus
  172 Coxsackieviruses, Echoviruses, and Numbered Enteroviruses (EV-A71, EVD-68, EVD-70)
  173 Parechoviruses
  174 Hepatitis A Virus
  175 Rhinovirus
  176 Noroviruses and Sapoviruses (Caliciviruses)
  177 Astroviruses and Picobirnaviruses
  178 Hepatitis E Virus
  B PRION DISEASES
  179 Prions and Prion Disease of the Central Nervous System (Transmissible Neurodegenerative Diseases)
  C CHLAMYDIAL DISEASES
  180 Chlamydia trachomatis (Trachoma and Urogenital Infections)
  181 Psittacosis (Due to Chlamydia psittaci)
  182 Chlamydia pneumoniae
  D MYCOPLASMA DISEASES
  183 Mycoplasma pneumoniae and Atypical Pneumonia
  184 Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species
  E RICKETTSIOSES, EHRLICHIOSES, AND ANAPLASMOSES
  185 Introduction to Rickettsioses, Ehrlichioses, and Anaplasmoses
  186 Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)
  187 Rickettsia akari (Rickettsialpox)
  188 Coxiella burnetii (Q Fever)
  189 Rickettsia prowazekii (Epidemic or Louse-Borne Typhus)
  190 Rickettsia typhi (Murine Typhus)
  191 Orientia tsutsugamushi (Scrub Typhus)
  192 Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae
  F BACTERIAL DISEASES
  193 Introduction to Bacteria and Bacterial Diseases
  194 Staphylococcus aureus (Including Staphylococcal Toxic Shock Syndrome)
  195 Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci
  196 Classification of Streptococci
  197 Streptococcus pyogenes
  198 Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis
  199 Streptococcus pneumoniae
  200 Enterococcus Species, Streptococcus gallolyticus Group, and Leuconostoc Species
  201 Streptococcus agalactiae (Group B Streptococci)
  202 Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci
  203 Streptococcus anginosus Group
  204 Corynebacterium diphtheriae (Diphtheria)
  205 Other Coryneform Bacteria, Arcanobacterium haemolyticum, and Rhodococci
  206 Listeria monocytogenes
  207 Bacillus anthracis (Anthrax)
  208 Bacillus Species and Related Genera Other Than Bacillus anthracis
  209 Erysipelothrix Rhusiopathiae
  210 Whipple Disease
  211 Neisseria meningitidis
  212 Neisseria gonorrhoeae (Gonorrhea)
  213 Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci
  214 Vibrio cholerae
  215 Other Pathogenic Vibrios
  216 Campylobacter jejuni and Related Species
  217 Helicobacter pylori and Other Gastric Helicobacter Species
  218 Enterobacteriaceae
  219 Pseudomonas aeruginosa and Other Pseudomonas Species
  220 Stenotrophomonas maltophilia and Burkholderia cepacia Complex
  221 Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and Glanders
  222 Acinetobacter Species
  223 Salmonella Species
  224 Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli
  225 Haemophilus Species, Including H. influenzae and H. ducreyi (Chancroid)
  226 Brucellosis (Brucella Species)
  227 Francisella tularensis (Tularemia)
  228 Pasteurella Species
  229A Plague (Yersinia pestis)
  229B Yersinia enterocolitica and Yersinia pseudotuberculosis
  230 Bordetella pertussis
  231 Rat-Bite Fever: Streptobacillus moniliformis and Spirillum minus
  232 Legionnaires’ Disease and Pontiac Fever
  233 Capnocytophaga
  234 Bartonella, Including Cat-Scratch Disease
  235 Klebsiella granulomatis (Donovanosis, Granuloma Inguinale)
  236 Other Gram-Negative and Gram-Variable Bacilli
  237 Syphilis (Treponema pallidum)
  238 Endemic Treponematoses
  239 Leptospira Species (Leptospirosis)
  240 Relapsing Fever Caused by Borrelia Species
  241 Lyme Disease (Lyme Borreliosis) Due to Borrelia burgdorferi
  242 Anaerobic Infections: General Concepts
  243 Clostridioides difficile (Formerly Clostridium difficile) Infection
  244 Tetanus (Clostridium tetani)
  245 Botulism (Clostridium botulinum)
  246 Diseases Caused by Clostridium
  247 Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli)
  248 Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli
  249 Mycobacterium tuberculosis
  250 Leprosy (Mycobacterium leprae)
  251 Mycobacterium avium Complex
  252 Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium avium Complex
  253 Nocardia Species
  254 Agents of Actinomycosis
  G MYCOSES
  255 Introduction to Mycoses
  256 Candida Species
  257 Aspergillus Species
  258 Agents of Mucormycosis and Entomophthoramycosis
  259 Sporothrix schenckii
  260 Agents of Chromoblastomycosis
  261 Agents of Mycetoma
  262 Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii)
  263 Histoplasma capsulatum (Histoplasmosis)
  264 Blastomycosis
  265 Coccidioidomycosis (Coccidioides Species)
  266 Dermatophytosis (Ringworm) and Other Superficial Mycoses
  267 Paracoccidioidomycosis
  268 Uncommon Fungi and Related Species
  269 Pneumocystis Species
  270 Microsporidiosis
  H PROTOZOAL DISEASES
  271 Introduction to Protozoal Diseases
  272 Entamoeba Species, Including Amebic Colitis and Liver Abscess
  273 Free-Living Amebae
  274 Malaria (Plasmodium Species)
  275 Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucosal Leishmaniasis
  276 Trypanosoma Species (American Trypanosomiasis, Chagas Disease): Biology of Trypanosomes
  277 Agents of African Trypanosomiasis (Sleeping Sickness)
  278 Toxoplasma gondii
  279 Giardia lamblia
  280 Trichomonas vaginalis
  281 Babesia Species
  282 Cryptosporidiosis (Cryptosporidium Species)
  283 Cyclospora cayetanensis, Cystoisospora belli, Sarcocystis Species, Balantidium coli, and Blastocystis Species
  I DISEASES DUE TO TOXIC ALGAE
  284 Human Illness Associated With Harmful Algal Blooms
  J DISEASES DUE TO HELMINTHS
  285 Introduction to Helminth Infections
  286 Intestinal Nematodes (Roundworms)
  287 Tissue Nematodes, Including Trichinellosis, Dracunculiasis, Filariasis, Loiasis, and Onchocerciasis
  288 Trematodes (Schistosomes and Liver, Intestinal, and Lung Flukes)
  289 Tapeworms (Cestodes)
  290 Visceral Larva Migrans and Other Uncommon Helminth Infections
• K ECTOPARASITIC DISEASES
  291 Introduction to Ectoparasitic Diseases
  292 Lice (Pediculosis)
  293 Scabies
  294 Myiasis and Tungiasis
  295 Mites, Including Chiggers
  296 Ticks, Including Tick Paralysis
  L DISEASES OF UNKNOWN ETIOLOGY
  297 Kawasaki Disease
  
• IV Special Problems
  A NOSOCOMIAL INFECTIONS
  298 Infection Prevention and Control in the Health Care Setting
  299 Disinfection, Sterilization, and Control of Hospital Waste
  300 Infections Caused by Percutaneous Intravascular Devices
  301 Nosocomial Pneumonia
  302 Health Care–Associated Urinary Tract Infections
  303 Health Care–Acquired Hepatitis
  304 Transfusion- and Transplantation-Transmitted Infections
• B INFECTIONS IN SPECIAL HOSTS
  305 Infections in the Immunocompromised Host: General Principles
  306 Prophylaxis and Empirical Therapy of Infection in Cancer Patients
  307 Infections in Recipients of Hematopoietic Stem Cell Transplants
  308 Infections in Solid-Organ Transplant Recipients
  309 Infections in Patients With Spinal Cord Injury
  310 nfections in Older Adults
  311 Infections in Asplenic Patients
  312 Infections in Injection Drug Users
  313 Surgical Site Infections and Antimicrobial Prophylaxis
• C SURGICAL- AND TRAUMA-RELATED INFECTIONS
  314 Burns
  315 Bites
• D IMMUNIZATION
  316 Immunization
  E ZOONOSES
  317 Zoonoses
• F PROTECTION OF TRAVELERS
  318 Protection of Travelers
  319 Infections in Returning Travelers

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